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1

High-throughput cytotoxicity and antigen-binding assay for screening small bispecific antibodies without purification

Sugiyama, Aruto, Umetsu, Mitsuo, Nakazawa, Hikaru, Niide, Teppei, Asano, Ryutaro, Hattori, Takamitsu, Kumagai, Izumi

Journal:

Journal of Bioscience and Bioengineering

Year:

2018

Language:

english

File:

PDF, 1.92 MB

english, 2018

2

Comprehensive study of domain rearrangements of single-chain bispecific antibodies to determine the best combination of configurations and microbial host cells

Asano, Ryutaro, Kuroki, Yuri, Honma, Sachiko, Akabane, Mihoko, Watanabe, Shunsuke, Mayuzumi, Shinzo, Hiyamuta, Shuichi, Kumagai, Izumi, Sode, Koji

Journal:

Year:

2018

Language:

english

File:

PDF, 2.54 MB

english, 2018

3

Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance

Suzuki, Saori, Annaka, Hiroaki, Konno, Shota, Kumagai, Izumi, Asano, Ryutaro

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.24 MB

english, 2018

4

Ultrastructure of the developing fibrocartilage of the Os penis of rat

Kazunari Izumi, Ikuo Yamaoka, Ryutaro Murakami

Journal:

Journal of Morphology

Year:

2000

Language:

english

File:

PDF, 507 KB

english, 2000

5

The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: Focus on genetic factors and urbanization

Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Nao Nishida, Ricky Eddie, Ryutaro Ohtsuka, Jun Ohashi

Journal:

American Journal of Human Biology

Year:

2011

Language:

english

File:

PDF, 462 KB

english, 2011

6

Brief communication: Mitochondrial DNA variation suggests extensive gene flow from Polynesian ancestors to indigenous Melanesians in the northwestern Bismarck Archipelago

Jun Ohashi, Izumi Naka, Katsushi Tokunaga, Tsukasa Inaoka, Yuji Ataka, Minato Nakazawa, Yasuhiro Matsumura, Ryutaro Ohtsuka

Journal:

American Journal of Physical Anthropology

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

7

Anomalous interconnection between flexor and extensor carpi radialis brevis tendons

Takahiro Nakahashi, Ryutaro Izumi

Journal:

The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology

Year:

1987

Language:

english

File:

PDF, 457 KB

english, 1987

8

Electrochemical screening of recombinant protein solubility in Escherichia coli using scanning electrochemical microscopy (SECM)

Kuniaki Nagamine, Shiho Onodera, Ai Kurihara, Tomoyuki Yasukawa, Hitoshi Shiku, Ryutaro Asano, Izumi Kumagai, Tomokazu Matsue

Journal:

Biotechnology and Bioengineering

Year:

2007

Language:

english

File:

PDF, 223 KB

english, 2007

9

Enhancement of Cellulolytic Enzyme Activity by Clustering Cellulose Binding Domains on Nanoscaffolds

Do-Myoung Kim, Mitsuo Umetsu, Kyo Takai, Takashi Matsuyama, Nobuhiro Ishida, Haruo Takahashi, Ryutaro Asano, Izumi Kumagai

Journal:

Year:

2011

Language:

english

File:

PDF, 858 KB

english, 2011

10

Glycosylation pattern of humanized IgG-like bispecific antibody produced by recombinant CHO cells

Wook-Dong Kim, Miwako Tokunaga, Hiroyuki Ozaki, Takuya Ishibashi, Kohsuke Honda, Hiroyuki Kajiura, Kazuhito Fujiyama, Ryutaro Asano, Izumi Kumagai, Takeshi Omasa, Hisao Ohtake

Journal:

Applied Microbiology and Biotechnology

Year:

2010

Language:

english

File:

PDF, 300 KB

english, 2010

11

A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells

Hiroki Hayashi, Ryutaro Asano, Kouhei Tsumoto, Yu Katayose, Masanori Suzuki, Michiaki Unno, Hideaki Kodama, Shin-ichi Takemura, Hiroshi Yoshida, Koki Makabe, Kohzoh Imai, Seiki Matsuno, Izumi Kumagai,

Journal:

Cancer Immunology, Immunotherapy

Year:

2004

Language:

english

File:

PDF, 525 KB

english, 2004

12

Mutated SEA-D227A-conjugated antibodies greatly enhance antitumor activity against MUC1-expressing bile duct carcinoma

Hideaki Kodama, Masanori Suzuki, Yu Katayose, Masao Shinoda, Naoki Sakurai, Shin-ichi Takemura, Hiroshi Yoshida, Hisaaki Saeki, Masahiko Ichiyama, Kohei Tsumoto, Ryutaro Asano, Izumi Kumagai, Kohzoh I

Journal:

Cancer Immunology, Immunotherapy

Year:

2001

Language:

english

File:

PDF, 291 KB

english, 2001

13

The Q223R polymorphism inLEPRis associated with obesity in Pacific Islanders

Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Yuji Ataka, Nao Nishida, Naoyuki Tsuchiya, Ryutaro O

Journal:

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

14

Polymorphisms in theABOblood group gene in three populations in the New Georgia group of the Solomon Islands

Jun Ohashi, Izumi Naka, Ryosuke Kimura, Katsushi Tokunaga, Taro Yamauchi, Kazumi Natsuhara, Takuro Furusawa, Rain Yamamoto, Minato Nakazawa, Takafumi Ishida, Ryutaro Ohtsuka

Journal:

Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 242 KB

english, 2006

15

Application of the Fc fusion format to generate tag-free bi-specific diabodies

Ryutaro Asano, Keiko Ikoma, Hiroko Kawaguchi, Yuna Ishiyama, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

Journal:

Year:

2010

Language:

english

File:

PDF, 711 KB

english, 2010

16

Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information

Mitsuo Umetsu, Takeshi Nakanishi, Ryutaro Asano, Takamitsu Hattori, Izumi Kumagai

Journal:

Year:

2010

Language:

english

File:

PDF, 499 KB

english, 2010

17

Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system

Ryutaro Asano, Makoto Nakayama, Hiroko Kawaguchi, Tsuguo Kubota, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

Journal:

Year:

2012

Language:

english

File:

PDF, 601 KB

english, 2012

18

TNF-α Increases Expression of IL-6 and ICAM-1 Genes Through Activation of NF-κB in Osteoblast-like ROS17/2.8 Cells

Kazutoshi Kurokouchi, Fukushi Kambe, Kou Yasukawa, Ryutaro Izumi, Naoki Ishiguro, Hisashi Iwata, Hisao Seo

Journal:

Journal of Bone and Mineral Research

Year:

1998

Language:

english

File:

PDF, 315 KB

english, 1998

19

Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of α2,6-sialyltransferase derived from Chinese hamster ovary cells

Masayoshi Onitsuka, Wook-Dong Kim, Hiroyuki Ozaki, Akira Kawaguchi, Kohsuke Honda, Hiroyuki Kajiura, Kazuhito Fujiyama, Ryutaro Asano, Izumi Kumagai, Hisao Ohtake, Takeshi Omasa

Journal:

Applied Microbiology and Biotechnology

Year:

2012

Language:

english

File:

PDF, 592 KB

english, 2012

20

Integration of PEGylation and refolding for renaturation of recombinant proteins from insoluble aggregates produced in bacteria—Application to a single-chain Fv fragment

Izumi Kumagai, Ryutaro Asano, Takeshi Nakanishi, Kentaro Hashikami, Sho Tanaka, Adel Badran, Hideaki Sanada, Mitsuo Umetsu

Journal:

Journal of Bioscience and Bioengineering

Year:

2010

Language:

english

File:

PDF, 629 KB

english, 2010

21

Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor

Kenji Nakano, Masatoshi Kobayashi, Kei-ichiro Nakamura, Takeshi Nakanishi, Ryutaro Asano, Izumi Kumagai, Hideaki Tahara, Michihiko Kuwano, Justus B. Cohen, Joseph C. Glorioso

Journal:

Year:

2011

Language:

english

File:

PDF, 1.44 MB

english, 2011

22

Cholinergic and glutamatergic transmission in medial vestibular nucleus neurons responding to lateral roll tilt in rats

Shinichiro Takeshita, Masashi Sasa, Kumatoshi Ishihara, Hiroaki Matsubayashi, Koji Yajin, Meiko Okada, Ryutaro Izumi, Kazunori Arita, Kaoru Kurisu

Journal:

Year:

1999

Language:

english

File:

PDF, 201 KB

english, 1999

23

Tumor-directed lymphocyte-activating cytokines: refolding-based preparation of recombinant human interleukin-12 and an antibody variable domain-fused protein by additive-introduced stepwise dialysis

Koki Makabe, Ryutaro Asano, Takahiko Ito, Kouhei Tsumoto, Toshio Kudo, Izumi Kumagai

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 653 KB

english, 2005

24

Grafting of material-binding function into antibodies: Functionalization by peptide grafting

Takamitsu Hattori, Mitsuo Umetsu, Takeshi Nakanishi, Kouhei Tsumoto, Satoshi Ohara, Hiroya Abe, Makio Naito, Ryutaro Asano, Tadafumi Adschiri, Izumi Kumagai

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 463 KB

english, 2008

25

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Norihiko Akamatsu, Yasuaki Yamada, Hiroo Hasegawa, Koki Makabe, Ryutaro Asano, Izumi Kumagai, Ken Murata, Yoshitaka Imaizumi, Kunihiro Tsukasaki, Kazuto Tsuruda, Kazuyuki Sugahara, Sunao Atogami, Kats

Journal:

Year:

2007

Language:

english

File:

PDF, 930 KB

english, 2007

26

Selection of human antibody fragments on the basis of stabilization of the variable domain in the presence of target antigens

Hideki Watanabe, Kouhei Tsumoto, Ryutaro Asano, Yoshiyuki Nishimiya, Izumi Kumagai

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 164 KB

english, 2002

27

Functional Fv fragment of an antibody specific for CD28: Fv-mediated co-stimulation of T cells

Shin-ichi Takemura, Ryutaro Asano, Kouhei Tsumoto, Takashi Arai, Naoki Sakurai, Hideaki Kodama, Hiroshi Yoshida, Yu Katayose, Masanori Suzuki, Seiki Matsuno, Toshio Kudo, Izumi Kumagai

Journal:

Year:

2000

Language:

english

File:

PDF, 394 KB

english, 2000

28

Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target

Kouhei Tsumoto, Satoru Misawa, Yoichi Ohba, Takamasa Ueno, Hideya Hayashi, Nobuhiro Kasai, Hideki Watanabe, Ryutaro Asano, Izumi Kumagai

Journal:

Year:

2002

Language:

english

File:

PDF, 220 KB

english, 2002

29

Antitumor activity of interleukin-21 prepared by novel refolding procedure from inclusion bodies expressed in Escherichia coli

Ryutaro Asano, Toshio Kudo, Koki Makabe, Kouhei Tsumoto, Izumi Kumagai

Journal:

Year:

2002

Language:

english

File:

PDF, 531 KB

english, 2002

30

Cholinergic and glutamatergic transmission in medial vestibular nucleus neurons responding to tilt stimulation

Shinichiro Takeshita, Masahi Sasa, Kumatoshi Ishihara, Hiroaki Matsubayashi, Koji Yajin, Meiko Okada, Ryutaro Izumi, Kaoru Kurisu

Journal:

Neuroscience Research

Year:

1998

Language:

english

File:

PDF, 115 KB

english, 1998

31

A nanocluster design for the construction of artificial cellulosomes

Kim, Do-Myoung, Nakazawa, Hikaru, Umetsu, Mitsuo, Matsuyama, Takashi, Ishida, Nobuhiro, Ikeuchi, Akinori, Takahashi, Haruo, Asano, Ryutaro, Kumagai, Izumi

Journal:

Catalysis Science & Technology

Year:

2012

Language:

english

File:

PDF, 1.87 MB

english, 2012

32

Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells

Lee, Kyoung Ho, Tsutsui, Tomomi, Honda, Kohsuke, Asano, Ryutaro, Kumagai, Izumi, Ohtake, Hisao, Omasa, Takeshi

Journal:

Journal of Bioscience and Bioengineering

Year:

2013

Language:

english

File:

PDF, 809 KB

english, 2013

33

Multimerization of anti-(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers

Asano, Ryutaro, Hagiwara, Yasuyo, Koyama, Noriaki, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi

Journal:

Year:

2013

Language:

english

File:

PDF, 744 KB

english, 2013

34

Trehalose suppresses antibody aggregation during the culture of Chinese hamster ovary cells

Onitsuka, Masayoshi, Tatsuzawa, Miki, Asano, Ryutaro, Kumagai, Izumi, Shirai, Akihiro, Maseda, Hideaki, Omasa, Takeshi

Journal:

Journal of Bioscience and Bioengineering

Year:

2014

Language:

english

File:

PDF, 694 KB

english, 2014

35

Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture

Onitsuka, Masayoshi, Kawaguchi, Akira, Asano, Ryutaro, Kumagai, Izumi, Honda, Kohsuke, Ohtake, Hisao, Omasa, Takeshi

Journal:

Journal of Bioscience and Bioengineering

Year:

2014

Language:

english

File:

PDF, 696 KB

english, 2014

36

Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse

Izumi, Ryutaro, Yamada, Takeshi, Yoshikai, Shun-ichi, Sasaki, Hiroyuki, Hattori, Masahira, Sakaki, Yoshiyuki

Journal:

Year:

1992

Language:

english

File:

PDF, 894 KB

english, 1992

37

Electrochemical Detection of Epidermal Growth Factor Receptors on a Single Living Cell Surface by Scanning Electrochemical Microscopy

Takahashi, Yasufumi, Miyamoto, Takeshi, Shiku, Hitoshi, Asano, Ryutaro, Yasukawa, Tomoyuki, Kumagai, Izumi, Matsue, Tomokazu

Journal:

Analytical Chemistry

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

38

A High-Affinity Gold-Binding Camel Antibody: Antibody Engineering for One-Pot Functionalization of Gold Nanoparticles as Biointerface Molecules

Hattori, Takamitsu, Umetsu, Mitsuo, Nakanishi, Takeshi, Sawai, Satoko, Kikuchi, Shinsuke, Asano, Ryutaro, Kumagai, Izumi

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

39

Electrochemical detection of receptor-mediated endocytosis by scanning electrochemical microscopy

Takahashi, Yasufumi, Miyamoto, Takeshi, Shiku, Hitoshi, Ino, Kosuke, Yasukawa, Tomoyuki, Asano, Ryutaro, Kumagai, Izumi, Matsue, Tomokazu

Journal:

Physical Chemistry Chemical Physics

Year:

2011

Language:

english

File:

PDF, 1.78 MB

english, 2011

40

Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia

Furusawa, Takuro, Naka, Izumi, Yamauchi, Taro, Natsuhara, Kazumi, Eddie, Ricky, Kimura, Ryosuke, Nakazawa, Minato, Ishida, Takafumi, Inaoka, Tsukasa, Matsumura, Yasuhiro, Ataka, Yuji, Ohtsuka, Ryutaro

Journal:

Journal of Human Genetics

Year:

2013

Language:

english

File:

PDF, 534 KB

english, 2013

41

Predictors of Mortality in Patients With Interstitial Lung Disease Treated With Corticosteroids

Migita, Kiyoshi, Arai, Toru, Jiuchi, Yuka, Izumi, Yasumori, Iwanaga, Nozomi, Kawahara, Chieko, Suematsu, Eiichi, Miyamura, Tomoya, Tsutani, Hiroshi, Kawabe, Yojiro, Matsumura, Ryutaro, Mori, Shunsuke,

Journal:

Medicine (Medicine Publishing Company Ltd)

Year:

2014

Language:

english

File:

PDF, 240 KB

english, 2014

42

Highly Enhanced Cytotoxicity of a Dimeric Bispecific Diabody, the hEx3 Tetrabody

Asano, Ryutaro, Ikoma, Keiko, Sone, Yukiko, Kawaguchi, Hiroko, Taki, Shintaro, Hayashi, Hiroki, Nakanishi, Takeshi, Umetsu, Mitsuo, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Kumagai, Izumi

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.20 MB

english, 2010

43

Organic crystal-binding peptides: morphology control and one-pot formation of protein-displaying organic crystals

Niide, Teppei, Ozawa, Kyohei, Nakazawa, Hikaru, Oliveira, Daniel, Kasai, Hitoshi, Onodera, Mari, Asano, Ryutaro, Kumagai, Izumi, Umetsu, Mitsuo

Journal:

Year:

2015

Language:

english

File:

PDF, 1.84 MB

english, 2015

44

Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus

Migita, Kiyoshi, Akeda, Yukihiro, Akazawa, Manabu, Tohma, Shigeto, Hirano, Fuminori, Ideguchi, Haruko, Matsumura, Ryutaro, Suematsu, Eiichi, Miyamura, Tomoya, Mori, Shunsuke, Fukui, Takahiro, Izumi, Y

Journal:

Arthritis Research & Therapy

Year:

2015

Language:

english

File:

PDF, 643 KB

english, 2015

45

Opsonic and Antibody Responses to Pneumococcal Polysaccharide in Rheumatoid Arthritis Patients Receiving Golimumab Plus Methotrexate

Migita, Kiyoshi, Akeda, Yukihiro, Akazawa, Manabu, Tohma, Shigeto, Hirano, Fuminori, Ideguchi, Haruko, Matsumura, Ryutaro, Suematsu, Eiichi, Miyamura, Tomoya, Mori, Shunsuke, Fukui, Takahiro, Izumi, Y

Journal:

Medicine (Medicine Publishing Company Ltd)

Year:

2015

Language:

english

File:

PDF, 367 KB

english, 2015

46

Anti-EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half-life

Asano, Ryutaro, Koyama, Noriaki, Hagiwara, Yasuyo, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi

Journal:

Year:

2016

Language:

english

File:

PDF, 403 KB

english, 2016

47

Diabody-based Recombinant Formats of Humanized IgG-like Bispecific Antibody With Effective Retargeting of Lymphocytes to Tumor Cells

Asano, Ryutaro, Kawaguchi, Hiroko, Watanabe, Yasuhiro, Nakanishi, Takeshi, Umetsu, Mitsuo, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Kumagai, Izumi

Journal:

Journal of Immunotherapy

Year:

2008

Language:

english

File:

PDF, 1.65 MB

english, 2008

48

A case of systemic lupus erythematosus with lupus anticoagulant, complicating cerebral infarctions and habitual abortions.

IZUMI, Ryutaro, MAYUMI, Takehito, NAGASAWA, Kohei, SHIBUYA, Tsunefumi, KUSABA, Tomohiro, YAMAUCHI, Yasuo, NIHO, Yoshiyuki, NAGANO, Masanori

Journal:

Nihon Naika Gakkai Zasshi

Year:

1987

File:

PDF, 173 KB

1987

49

The Use of Cervical Spine Locking Plate in Degenerative Cervical Spine Disease.

Fujimoto, Tooru, Hayashi, Yasuo, Izumi, Seiji, Date, Tooru, Tsurukami, Hiroshi, Kinuhara, Hiroshi, Ito, Ryutaro, Miyamoto, Takeshi

Journal:

Orthopedics & Traumatology

Year:

1996

Language:

english

File:

PDF, 1.20 MB

english, 1996

50

Functionalization of Bispecific Therapeutic Antibodies Based on Protein Engineering

Asano, Ryutaro, Kumagai, Izumi

Journal:

YAKUGAKU ZASSHI

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015